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Description for Protein CTGF

connective tissue growth factor
10 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(alpha granules: 1; platelet: 1; secretome: 1)
Summary:
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • VWC: von Willebrand factor (vWF) type C domain
  • TSP1: Thrombospondin type 1 repeats
  • CT: C-terminal cystine knot-like domain (CTCK)
  • IB: Insulin growth factor-binding protein homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06827
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Insulin like growth factor-binding protein 8; CCN2; NOV2; Hypertrophic chondrocyte specific protein 24; HCS24; IGFBP8; FISP 12 protein; Hypertrophic chondrocyte-specific protein 24
    Approved Symbol:
    CTGF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00412 Entrez Gene ID: 1490 OMIM ID: 121009 Swissprot Accession: P29279; Q5M8T4;