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Description for Protein TICAM1

toll-like receptor adaptor molecule 1
21 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
TRIF, or TICAM1, is a Toll/IL1R (MIM 147810) (TIR) domain-containing adaptor molecule, like MYD88 (MIM 602170) and TIRAP (MIM 606252), that induces interferon-beta (IFNB; MIM 147640), specifically interacts with TLR3 (MIM 603029), and activates nuclear factor kappa-B (NFKB; see MIM 164011).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TIR: Toll - interleukin 1 - resistance
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05842
    KEGG - Pathway(s):
    hsa04620; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Tir domain containing adaptor inducing interferon beta; TRIF; Tir domain containing adaptor molecule 1; PRVTIRB; TICAM-1; MGC35334; TIR domain containing adaptor inducing interferon-beta isoform 2
    Approved Symbol:
    TICAM1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06350 Entrez Gene ID: 148022 OMIM ID: 607601 Swissprot Accession: Q8IUC6;