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Description for Protein ADRA1A

adrenergic, alpha-1A-, receptor
10 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04135
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04270; hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Alpha 1A adrenoceptor; Alpha 1C adrenergic receptor; ADRA1C; ADRA1L1; ALPHA1AAR; Alpha 1A adrenergic receptor isoform 1; Alpha 1A adrenergic receptor isoform 4; Alpha 1A adrenergic receptor, isoform 2; Alpha 1A -3A
    Approved Symbol:
    ADRA1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-Methoxyamphetamine(db);
  • Acepromazine(db);
  • Alfuzosin(db);
  • Amitriptyline(db);
  • Amoxapine(db);
  • Apraclonidine(db);
  • Aripiprazole(db);
  • Benzphetamine(db);
  • Bevantolol(db);
  • Bromocriptine(db);
  • Carvedilol(db);
  • Chlorpromazine(db);
  • Clozapine(db);
  • Dapiprazole(db);
  • Desipramine(db);
  • Dextroamphetamine(db);
  • Dihydroergotoxine(db);
  • Dipivefrin(db);
  • Doxazosin(db);
  • Doxepin(db);
  • Droperidol(db);
  • Droxidopa(db);
  • Ephedrine(db);
  • Epinastine(db);
  • Epinephrine(db);
  • Ergoloid mesylate(db);
  • Ergonovine(db);
  • Ergotamine(db);
  • Escitalopram(db);
  • Flupenthixol(db);
  • Imipramine(db);
  • Isometheptene(db);
  • Labetalol(db);
  • Levonordefrin(db);
  • Maprotiline(db);
  • Mephentermine(db);
  • Metaraminol(db);
  • Methotrimeprazine(db);
  • Methoxamine(db);
  • Midodrine(db);
  • Naphazoline(db);
  • Nefazodone(db);
  • Nicardipine(db);
  • Nicergoline(db);
  • Norepinephrine(db);
  • Nortriptyline(db);
  • Olanzapine(db);
  • Oxymetazoline(db);
  • Paliperidone(db);
  • Pergolide(db);
  • Phendimetrazine(db);
  • Phenoxybenzamine(db);
  • Phentolamine(db);
  • Phenylephrine(db);
  • Phenylpropanolamine(db);
  • Prazosin(db);
  • Promazine(db);
  • Promethazine(db);
  • Propiomazine(db);
  • Pseudoephedrine(db);
  • Quetiapine(db);
  • Risperidone(db);
  • Sertindole(db);
  • Tamsulosin(db);
  • Terazosin(db);
  • Thioproperazine(db);
  • Thioridazine(db);
  • Tolazoline(db);
  • Trazodone(db);
  • Trifluoperazine(db);
  • Trimipramine(db);
  • Xylometazoline(db);
  • Ziprasidone(db);
  • Zuclopenthixol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 7
  • Isoform 3 : 7
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00081 Entrez Gene ID: 148 OMIM ID: 104221 Swissprot Accession: P35348; B0ZBD3;