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Description for Protein ADRA1B

adrenergic, alpha-1B-, receptor
11 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04136
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04270; hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Alpha 1 adrenergic receptor; ADRA1; Alpha 1B adrenoceptor
    Approved Symbol:
    ADRA1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acepromazine(db);
  • Alfuzosin(db);
  • Aripiprazole(db);
  • Bromocriptine(db);
  • Chlorpromazine(db);
  • Clozapine(db);
  • Dapiprazole(db);
  • Dextroamphetamine(db);
  • Doxazosin(db);
  • Doxepin(db);
  • Droxidopa(db);
  • Epinephrine(db);
  • Ergotamine(db);
  • Labetalol(db);
  • Lisdexamfetamine(db);
  • Methotrimeprazine(db);
  • Methoxamine(db);
  • Midodrine(db);
  • Modafinil(db);
  • Nefazodone(db);
  • Nicardipine(db);
  • Norepinephrine(db);
  • Olanzapine(db);
  • Paliperidone(db);
  • Pergolide(db);
  • Phendimetrazine(db);
  • Phenylephrine(db);
  • Prazosin(db);
  • Promazine(db);
  • Propericiazine(db);
  • Propiomazine(db);
  • Quetiapine(db);
  • Risperidone(db);
  • Sertindole(db);
  • Tamsulosin(db);
  • Terazosin(db);
  • Thioproperazine(db);
  • Thioridazine(db);
  • Trimipramine(db);
  • Xylometazoline(db);
  • Ziprasidone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00080 Entrez Gene ID: 147 OMIM ID: 104220 Swissprot Accession: P35368;