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Description for Protein EME1

essential meiotic endonuclease 1 homolog 1 (S. pombe)
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.22.-
    KEGG - Orthology:
    K10882
    KEGG - Pathway(s):
    hsa03440
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MMS4L; FLJ31364; EME1 endonuclease; Essential meiotic endonuclease 1 homolog 1; Essential meiotic endonuclease 1 homolog 2
    Approved Symbol:
    EME1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10937 Entrez Gene ID: 146956 OMIM ID: 610885 Swissprot Accession: Q96AY2;