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Description for Protein CSNK2A1

casein kinase 2, alpha 1 polypeptide
192 total interacting proteins; 89 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 6)
Summary:
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K03097
    KEGG - Pathway(s):
    hsa04310; hsa04520; hsa04530
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Casein kinase II alpha 1 subunit isoform a; Casein kinase II alpha 1 subunit isoform b; CK2 catalytic subunit alpha; Casein kinase II alpha subunit; Casein kinase II alpha 1 subunit; Protein kinase CK2; CK2, alpha 1; CK II; Casein kinase II; CK2A1; Casein kinase II, alpha chain; EC 2.7.1.37
    Approved Symbol:
    CSNK2A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 29
    Human (de-) phosphorylation sites: 29; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 286
    Human phosphorylation targets: 210; Predicted platelet targets: 87
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid(db);
  • 1,2,5,8-tetrahydroxyanthracene-9,10-dione(db);
  • 1,8-Di-Hydroxy-4-Nitro-Anthraquinone(db);
  • 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One(db);
  • 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one(db);
  • 2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione(db);
  • 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE(db);
  • 2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE(db);
  • 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE(db);
  • 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE(db);
  • 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE(db);
  • 4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE(db);
  • 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole(db);
  • 5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone(db);
  • Benzamidine(db);
  • DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE(db);
  • N,N'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE(db);
  • N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE(db);
  • N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE(db);
  • Phosphoaminophosphonic Acid-Adenylate Ester(db);
  • Resveratrol(db);
  • S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE(db);
  • Tetrabromo-2-Benzotriazole(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00277 Entrez Gene ID: 1457 OMIM ID: 115440 Swissprot Accession: P68400; B4DYS6;