Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein PRICKLE1

prickle homolog 1 (Drosophila)
4 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LIM: Zinc-binding domain present in Lin-11, Isl-1, Mec-3.
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04511
    KEGG - Pathway(s):
    hsa04310
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Prickle like protein 1; REST/NRSF interacting LIM domain protein 1; REST (RE-1 silencing transcription factor)/NRSF (neuron restrictive silencer factor) interacting LIM domain protein; RILP; REST interacting LIM domain protein; FLJ31937
    Approved Symbol:
    PRICKLE1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16341 Entrez Gene ID: 144165 OMIM ID: 608500 Swissprot Accession: Q96MT3; B3KVG3; B3KVG6;