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Description for Protein CSF3R

colony stimulating factor 3 receptor (granulocyte)
18 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05061
    KEGG - Pathway(s):
    hsa04060; hsa04630; hsa04640; hsa05200
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Granulocyte colony stimulating factor receptor; GCSFR; CD114 antigen; Colony stimulating factor 3 receptor isoform a; Colony stimulating factor 3 receptor isoform d; Colony stimulating factor 3 receptor isoform b; Colony stimulating factor 3 receptor isoform c
    Approved Symbol:
    CSF3R
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Filgrastim(db);
  • Pegfilgrastim(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00737 Entrez Gene ID: 1441 OMIM ID: 138971 Swissprot Accession: Q99062;