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Description for Protein CSF2RB

colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
27 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04738
    KEGG - Pathway(s):
    hsa04060; hsa04210; hsa04630
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Colony-stimulating factor-2 receptor, beta, low-affinity; Granulocyte macrophage colony stimulating factor receptor, beta; Interleukin 5 receptor, beta; IL5RB; IL3RB; CD131
    Approved Symbol:
    CSF2RB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-D-Mannose(db);
  • Fucose(db);
  • Sargramostim(db)

    Associated Genetic Diseases:

  • Pulmonary alveolar proteinosis(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00739 Entrez Gene ID: 1439 OMIM ID: 138981 Swissprot Accession: P32927; Q6NSJ8;