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Description for Protein CSF1

colony stimulating factor 1 (macrophage)
11 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05453
    KEGG - Pathway(s):
    hsa04060; hsa04640
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Colony stimulating factor 1 isoform a precursor; Colony stimulating factor 1 isoform b; Lanimostim; Colony stimulating factor 1 isoform c; Colony stimulating factor 1 isoform a; M CSF; Macrophage colony stimulating factor 1; Macrophage granulocyte inducer IM; MGI-IM
    Approved Symbol:
    CSF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00388 Entrez Gene ID: 1435 OMIM ID: 120420 Swissprot Accession: P09603;