Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein CS

citrate synthase
7 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(microparticles: 1; platelet: 5; secretome: 3)
Summary:
The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.3.1
    KEGG - Orthology:
    K01647
    KEGG - Pathway(s):
    hsa00020; hsa00630; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Citrate synthase precursor isoform b; Citrate synthase mitochondrial; EC 2.3.3.1
    Approved Symbol:
    CS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-Fluoro-Carboxymethyldethia Coenzyme a Complex(db);
  • Citric Acid(db);
  • Coenzyme A(db);
  • Malate Ion(db);
  • Nitromethyldethia Coenzyme A(db);
  • Oxaloacetate Ion(db);
  • Trifluoroacetonyl Coenzyme A(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00349 Entrez Gene ID: 1431 OMIM ID: 118950 Swissprot Accession: O75390;