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Description for Protein DUSP19

dual specificity phosphatase 19
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • DSPC: Dual specificity phosphatase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.16; 3.1.3.48
    KEGG - Orthology:
    K01090
    K01104
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SKRP1; DUSP17; TS-DSP1; Dual specificity protein phosphatase 19; Protein phosphatase SKRP1; Protein phosphatase; Stress activated protein kinase pathway-regulating phosphatase 1; LMW-DSP3
    Approved Symbol:
    DUSP19
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 13254 Entrez Gene ID: 142679 OMIM ID: 611437 Swissprot Accession: Q8WTR2;