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Description for Protein PARP1

poly (ADP-ribose) polymerase 1
74 total interacting proteins; 23 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • BRCT: breast cancer carboxy-terminal domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.4.2.30
    KEGG - Orthology:
    K10798
    KEGG - Pathway(s):
    hsa03410
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ADPRT1; Poly(ADP ribose) polymerase; PPOL; Poly(ADP ribose) polymerase 1; Poly(ADP ribose) synthetase; ADP-ribosyltransferase NAD(+); PARP
    Approved Symbol:
    PARP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium(db);
  • 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide(db);
  • 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide(db);
  • 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone(db);
  • 3,4-Dihydro-5-Methyl-Isoquinolinone(db);
  • 3-Methoxybenzamide(db);
  • 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE(db);
  • 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE(db);
  • Carba-Nicotinamide-Adenine-Dinucleotide(db);
  • Nicotinamide(db);
  • NU1025(db);
  • trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01435 Entrez Gene ID: 142 OMIM ID: 173870 Swissprot Accession: P09874;