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Description for Protein CRKL

v-crk sarcoma virus CT10 oncogene homolog (avian)-like
52 total interacting proteins; 31 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(microparticles: 1; platelet: 5; secretome: 1)
Summary:
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic. (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04438
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04510; hsa04666; hsa04722; hsa04810; hsa04910; hsa05100; hsa05131; hsa05200; hsa05211; hsa05220
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    -
    Approved Symbol:
    CRKL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03596 Entrez Gene ID: 1399 OMIM ID: 602007 Swissprot Accession: P46109;