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Description for Protein CRK

v-crk sarcoma virus CT10 oncogene homolog (avian)
76 total interacting proteins; 41 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04438
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04510; hsa04666; hsa04722; hsa04810; hsa04910; hsa05100; hsa05131; hsa05200; hsa05211; hsa05220
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CRKII; v-crk sarcoma virus CT10 oncogene homolog isoform b; v-crk sarcoma virus CT10 oncogene homolog isoform a; v-crk sarcoma virus CT10 oncogene homolog
    Approved Symbol:
    CRK
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01267 Entrez Gene ID: 1398 OMIM ID: 164762 Swissprot Accession: P46108; Q96GA9;