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Description for Protein CREM

cAMP responsive element modulator
23 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BRLZ: basic region leucin zipper
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Inducible cAMP early repressor ICER; cAMP responsive element modulator isoform r; cAMP responsive element modulator isoform q; cAMP responsive element modulator isoform 1; cAMP responsive element modulator isoform m; cAMP responsive element modulator isoform n; cAMP responsive element modulator isoform o; cAMP responsive element modulator isoform p; cAMP responsive element modulator isoform u; cAMP responsive element modulator isoform t; cAMP responsive element modulator isoform s; cAMP responsive element modulator isoform v; cAMP responsive element modulator isoform b; cAMP responsive element modulator isoform d; cAMP responsive element modulator isoform e; cAMP responsive element modulator isoform f; cAMP responsive element modulator isoform g; cAMP responsive element modulator isoform h; cAMP responsive element modulator isoform i; cAMP responsive element modulator isoform k; CREM 22; hCREM type1 alpha; ICER11; hCREM 2 beta b; hCREM 2 beta a; ICER11 gamma; ICER1 gamma; hCREM 2 alpha b; CREM theta 2 beta; Repressor isoform theta 2; CREM theta 1 tau 2 beta; Activator isoform theta 1; CREM theta 1 beta; Repressor isoform theta 1; CREM 10; hCREM-2; Hypothetical protein MGC17881; Hypothetical protein MGC41893; Hypothetical protein MGC111110; activator tau2 isoform; ICER1; hCREM 2 alpha a; cAMP responsive element modulator isoform a; cAMP responsive element modulator isoform j; ICER
    Approved Symbol:
    CREM
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 84
    Human (de-) phosphorylation sites: 84; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
    00444_22(0)
    00444_21(0)
    00444_20(0)
    00444_19(0)
    00444_18(0)
    00444_17(0)
    00444_16(0)
    00444_15(0)
    00444_14(0)
    00444_13(0)
    00444_12(0)
    00444_11(0)
  • Isoform 9 : 0
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00444 Entrez Gene ID: 1390 OMIM ID: 123812 Swissprot Accession: A8MPQ2; Q03060; Q14501;