Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein CREBBP

CREB binding protein
248 total interacting proteins; 72 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BROMO: bromo domain
  • CC: Coiled Coil
  • ZnF_ZZ: Zinc-binding domain, present in Dystrophin, CREB-binding protein.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.1.48
    KEGG - Orthology:
    K04498
    KEGG - Pathway(s):
    hsa04110; hsa04310; hsa04330; hsa04350; hsa04520; hsa04630; hsa04720; hsa04916; hsa05016; hsa05200; hsa05211; hsa05215
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CBP; CREB binding protein; CREB binding protein isoform b
    Approved Symbol:
    CREBBP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 57
    Human (de-) phosphorylation sites: 57; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE(db)

    Associated Genetic Diseases:

  • Rubinstein-Taybi syndrome(Pd);
  • Rubinstein-Taybi syndrome, incomplete(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02534 Entrez Gene ID: 1387 OMIM ID: 600140 Swissprot Accession: Q92793; Q4LE28;