Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein CREB1

cAMP responsive element binding protein 1
86 total interacting proteins; 27 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BRLZ: basic region leucin zipper
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05870
    KEGG - Pathway(s):
    hsa04612; hsa04916; hsa04962; hsa05016; hsa05215
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    cAMP responsive element binding protein 1 isoform A; cAMP responsive element binding protein 1 isoform B; CREB; Transactivator protein; cAMP response element-binding protein 1; cAMP response element binding protein
    Approved Symbol:
    CREB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 28
    Human (de-) phosphorylation sites: 28; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine monophosphate(db);
  • Naloxone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00442 Entrez Gene ID: 1385 OMIM ID: 123810 Swissprot Accession: P16220; Q5U0J5; Q53X93;