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Description for Protein CRAT

carnitine O-acetyltransferase
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 5)
Summary:
This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Alternate splicing results in multiple transcript variants; additional transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.3.1.7
KEGG - Orthology:
K00624
KEGG - Pathway(s):
hsa04146
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Carnitine acetyltransferase isoform 2; CAT1; Carnitine acetylase; CAT; Carnitine O-acetyltransferase; Carnitine acetyltransferase isoform 1
Approved Symbol:
CRAT
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium(db);
  • Coenzyme A(db);
  • L-Carnitine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08971 Entrez Gene ID: 1384 OMIM ID: 600184 Swissprot Accession: P43155;