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Description for Protein CR2

complement component (3d/Epstein Barr virus) receptor 2
12 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SUSHI: Sushi domain (SCR repeat)
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04012
    KEGG - Pathway(s):
    hsa04610; hsa04640; hsa04662
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Complement component 3d/Epstein Barr virus receptor 2 isoform 1; Complement component 3d/Epstein Barr virus receptor 2 isoform 2; CD21; Cr2; Complement C3d receptor; C3DR; Epstein-Barr virus receptor; EBV receptor
    Approved Symbol:
    CR2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00399 Entrez Gene ID: 1380 OMIM ID: 120650 Swissprot Accession: Q53EL2; P20023; Q5SR46;