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Description for Protein CPN1

carboxypeptidase N, polypeptide 1
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • Zn_pept: Alpha-L-fucosidase
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.17.3
    KEGG - Orthology:
    K01292
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Arginine carboxypeptidase; Kininase 1; SCPN; Anaphylatoxin inactivator; Plasma carboxypeptidase B; Carboxypeptidase B N, catalytic subunit; Carboxypeptidase N, polypeptide 1, 50kD; Carboxypeptidase B, serum; CPN
    Approved Symbol:
    CPN1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Carboxypeptidase N deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09120 Entrez Gene ID: 1369 OMIM ID: 603103 Swissprot Accession: P15169; B1AP59;