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Description for Protein CPB2

carboxypeptidase B2 (plasma)
5 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Available sequence data analyses indicate splice variants that encode different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • Zn_pept: Alpha-L-fucosidase
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.17.20
    KEGG - Orthology:
    K01300
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Plasma carboxypeptidase B2 isoform b; CPU; PCPB; TAFI; BA139H14.2 carboxypeptidase B2 plasma; Carboxypeptidase B-like protein; Carboxypeptidase U; Plasma carboxypeptidase B2; Thrombin-activable fibrinolysis inhibitor; Thrombin-activatable fibrinolysis inhibitor; EC 3.4.17.20; Plasma carboxypeptidase B; Plasma carboxypeptidase B2 isoform a preproprotein
    Approved Symbol:
    CPB2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04374 Entrez Gene ID: 1361 OMIM ID: 603101 Swissprot Accession: Q96IY4;