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Description for Protein CP

ceruloplasmin (ferroxidase)
7 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 1; secretome: 1)
Summary:
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.16.3.1
    KEGG - Orthology:
    K13624
    KEGG - Pathway(s):
    hsa00860
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Ferroxidase; EC 1.16.3.1
    Approved Symbol:
    CP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Drotrecogin alfa(db)

    Associated Genetic Diseases:

  • Aceruloplasminemia(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00317 Entrez Gene ID: 1356 OMIM ID: 117700 Swissprot Accession: P00450; A5PL27;