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Description for Protein CD109

CD109 molecule
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(alpha granules: 1; membrane: 1; undefined: 1)
Summary:
This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06530
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Gov platelet alloantigens; FLJ38569; DKFZp762L1111; Gov system alloantigens on platelets
    Approved Symbol:
    CD109
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10590 Entrez Gene ID: 135228 OMIM ID: 608859 Swissprot Accession: Q6YHK3;