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Description for Protein ADORA2A

adenosine A2a receptor
8 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/2)
(platelet: 1; undefined: 1)
Summary:
This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04266
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04270
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ADORA2; RDC8
    Approved Symbol:
    ADORA2A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol(db);
  • Adenosine(db);
  • Caffeine(db);
  • Defibrotide(db);
  • Dyphylline(db);
  • Mefloquine(db);
  • Oxtriphylline(db);
  • Pentoxifylline(db);
  • Theobromine(db);
  • Theophylline(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00043 Entrez Gene ID: 135 OMIM ID: 102776 Swissprot Accession: P29274; B3KVQ4;