Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein COMT

catechol-O-methyltransferase
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 7)
Summary:
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.1.1.6
    KEGG - Orthology:
    K00545
    KEGG - Pathway(s):
    hsa00140; hsa00350; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Catechol-O-methyltransferase, soluble form; S-COMT; Catechol-O-methyltransferase isoform S-COMT; Catechol-O-methyltransferase isoform MB-COMT; EC 2.1.1.6
    Approved Symbol:
    COMT
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE(db);
  • 3,5-Dinitrocatechol(db);
  • 7,8-dihydroxy-4-phenyl-2H-chromen-2-one(db);
  • BIA(db);
  • Entacapone(db);
  • N-{3-[5-(6-Amino-Purin-9-Yl)-3,4-Dihydroxy-Tetrahydro-Furan-2-Yl]-Allyl}-2,3-Dihydroxy-5-Nitro-Benzamide(db);
  • Tolcapone(db)

    Associated Genetic Diseases:

  • Catechol-O-methyltransferase polymorphism(Pd);
  • Schizophrenia, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00284 Entrez Gene ID: 1312 OMIM ID: 116790 Swissprot Accession: P21964;