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Description for Protein COMP

cartilage oligomeric matrix protein
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • EGFCA: Calcium-binding EGF-like domain
  • CC: Coiled Coil
  • EGFL: EGF domain, unclasssified subfamily
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04659
    KEGG - Pathway(s):
    hsa04350; hsa04510; hsa04512; hsa05144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    EDM1
    Approved Symbol:
    COMP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Calcium(db)

    Associated Genetic Diseases:

  • Epiphyseal dysplasia, multiple, 1(Pd);
  • Epiphyseal dysplasia, multiple, Fairbank type(Pd);
  • Epiphyseal dysplasia, multiple, Ribbing type(Pd);
  • Pseudoachondroaplasia(Pd);
  • Pseudoachondroplasia(Pd);
  • Pseudoachondroplasia, severe(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02632 Entrez Gene ID: 1311 OMIM ID: 600310 Swissprot Accession: P49747;