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Description for Protein ADH5

alcohol dehydrogenase 5 (class III), chi polypeptide
5 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(microparticles: 1; platelet: 2; secretome: 1)
Summary:
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.1; 1.1.1.284
KEGG - Orthology:
K00121
KEGG - Pathway(s):
hsa00010; hsa00071; hsa00350; hsa00830; hsa00980; hsa00982; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Alcohol dehydrogenase, chi isozyme; ADH, class III; ADHX; Alcohol dehydrogenase class III, chi chain; Glutathione dependent formaldehyde dehydrogenase; EC 1.1.1.1; EC 1.2.1.1
Approved Symbol:
ADH5
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 12-Hydroxydodecanoic Acid(db);
  • Lauric Acid(db);
  • NADH(db);
  • Nicotinamide-Adenine-Dinucleotide(db);
  • S-Hydroxymethyl Glutathione(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00064 Entrez Gene ID: 128 OMIM ID: 103710 Swissprot Accession: P11766; Q6IRT1;