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Description for Protein UHMK1

U2AF homology motif (UHM) kinase 1
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
  • RRM: RNA recognition motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K08877
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    KIS; U2AF homology motif (UHM) kinase 1; Kist; KIS protein kinase; kinase interacting with leukemia-associated gene (stathmin); Serine/threonine-protein kinase Kist; EC 2.7.1.37; U2AF homology motif kinase 1
    Approved Symbol:
    UHMK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 4
    Human phosphorylation targets: 4; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 12318 Entrez Gene ID: 127933 OMIM ID: 608849 Swissprot Accession: Q8TAS1;