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Description for Protein NDUFA11

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes a subunit of the membrane-bound mitochondrial complex I. Complex I is composed of numerous subunits and functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain. Mutations in this gene are associated with severe mitochondrial complex I deficiency. Alternate splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.6.5.3
    KEGG - Orthology:
    K03956
    KEGG - Pathway(s):
    hsa00190; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    B14.7; CI-B14.7; EC 1.6.5.3; EC 1.6.99.3; Complex I-B14.7; NADH ubiquinone oxidoreductase subunit B14.7
    Approved Symbol:
    NDUFA11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • NADH(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 14818 Entrez Gene ID: 126328 OMIM ID: 612638 Swissprot Accession: Q86Y39;