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Description for Protein CCR5

chemokine (C-C motif) receptor 5
42 total interacting proteins; 28 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04180
    KEGG - Pathway(s):
    hsa04060; hsa04062; hsa04144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Chemokine, CC motif, receptor 5; HIV-1 fusion coreceptor; CCCKR5; CMKBR5; CKR5; Chemr13
    Approved Symbol:
    CCR5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Maraviroc(db)

    Associated Genetic Diseases:

  • CCR5 polymorphism, African-American(Pd);
  • CCR5 polymorphism, oriental 1(Pd);
  • CCR5 polymorphism, oriental 2(Pd);
  • CCR5 promoter polymorphism(Pd);
  • Human immunodeficiency virus type 1, resistance to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 6
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 03223 Entrez Gene ID: 1234 OMIM ID: 601373 Swissprot Accession: P51681; Q38L21;