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Description for Protein PPIL5

peptidylprolyl isomerase (cyclophilin)-like 5
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LRR: Leucine-rich repeats, outliers
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10348
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Peptidylprolyl isomerase (cyclophilin)-like 5; Peptidylprolyl isomerase (cyclophilin)-like 5 isoform 1; Peptidylprolyl isomerase (cyclophilin)-like 5 isoform 3; Cyclophilin like 5; LRR 1; 4-1BBLRR; MGC20689; LRR repeat protein 1; 4-1BB-mediated signaling molecule; LRR-1a
    Approved Symbol:
    PPIL5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15164 Entrez Gene ID: 122769 OMIM ID: 609193 Swissprot Accession: Q96L50; Q6AWA7;