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Description for Protein CLTC

clathrin, heavy chain (Hc)
57 total interacting proteins; 37 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/1)
(membrane: 2; microparticles: 1; platelet: 4; secretome: 2; undefined: 1)
Summary:
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CLH: Clathrin heavy chain repeat homology
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04646
    KEGG - Pathway(s):
    hsa04142; hsa04144; hsa05016; hsa05100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Clathrin heavy polypeptide like 2; CLH 17; CLTC/TFE3 Fusion gene
    Approved Symbol:
    CLTC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00350 Entrez Gene ID: 1213 OMIM ID: 118955 Swissprot Accession: Q00610;