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Description for Protein LRRK2

leucine-rich repeat kinase 2
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LRR: Leucine-rich repeats, outliers
  • Small_GTPase: Small GTPase of the Ras superfamily
  • ill-defined subfamily
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
  • WD40: WD40 repeats
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K08844
    KEGG - Pathway(s):
    hsa05012
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PARK8; ROCO2; FLJ45829; Dardarin
    Approved Symbol:
    LRRK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 73
    Human (de-) phosphorylation sites: 73; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 4
    Human phosphorylation targets: 4; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10613 Entrez Gene ID: 120892 OMIM ID: 609007 Swissprot Accession: Q5S007; Q17RV3;