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Description for Protein CLK1

CDC-like kinase 1
16 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.12.1
    KEGG - Orthology:
    K08823
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    STY; Protein tyrosine kinase STY; CLK; Dual specificity protein kinase CLK1; CDC28/CDC2 like kinase; CLK/STY; CDC-like kinase 1; EC 2.7.1.37; EC 2.7.1.112; CDC-like kinase 1 isoform 1; CDC-like kinase 1 isoform 2
    Approved Symbol:
    CLK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 29
    Human phosphorylation targets: 2; Predicted platelet targets: 27
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Debromohymenialdisine(db);
  • ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09058 Entrez Gene ID: 1195 OMIM ID: 601951 Swissprot Accession: P49759; B4DFW7;