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Description for Protein CLU

clusterin
17 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/2)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 7; secretome: 4; undefined: 1)
Summary:
The protein encoded by this gene appears to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. However, the function of this protein is unknown. Three transcript variants encoding different isoforms have been found for this gene, and one of them is secreted and processed into a mature form. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Apolipoprotein J; APOJ; Sulfated glycoprotein 2; SGP2; Complement associated protein SP-40,40; Complement lysis inhibitor; Complement cytolysis inhibitor; CLI; Testosterone repressed prostate message 2; TRPM2; NA1; NA2; Clusterin isoform 2; Clusterin isoform 1
    Approved Symbol:
    CLU
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01706 Entrez Gene ID: 1191 OMIM ID: 185430 Swissprot Accession: P10909;