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Description for Protein CLCN6

chloride channel 6
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • CBS: Domain in cystathionine beta-synthase and other proteins.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05015
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    CLC6; ClC-6; Chloride channel protein 6; Chloride channel 6 isoform ClC-6b; Chloride channel 6 isoform ClC-6c; Chloride channel 6 isoform ClC-6d; chloride channel 6 isoform ClC-6a
    Approved Symbol:
    CLCN6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 3
  • Isoform 3 : 3
  • Isoform 2 : 3
  • Isoform 1 : 9
    • Additional Identifiers:

    HPRD: 04102 Entrez Gene ID: 1185 OMIM ID: 602726 Swissprot Accession: P51797;