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Description for Protein AP2M1

adaptor-related protein complex 2, mu 1 subunit
41 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; platelet: 10)
Summary:
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K11826
KEGG - Pathway(s):
hsa04144; hsa05016
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Clathrin associated/assembly/adaptor protein medium 1; CLAPM1; Clathrin adaptor protein 50; AP50; Adaptor related protein complex 2, MU 1 subunit; Clathrin coat assembly/associated protein Ap50; Plasma membrane adaptor Ap2 50kDa protein; AP2 mu 2 chain; HA2 50 kDA subunit; Adaptor-related protein complex 2, mu 1 subunit isoform a; KIAA0109; Adaptor-related protein complex 2, mu 1 subunit isoform b
Approved Symbol:
AP2M1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 11
Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03014 Entrez Gene ID: 1173 OMIM ID: 601024 Swissprot Accession: Q96CW1;