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Description for Protein AGAP1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
CENTG2 belongs to an ADP-ribosylation factor GTPase-activating (ARF-GAP) protein family involved in membrane traffic and actin cytoskeleton dynamics (Nie et al., 2002 [PubMed 12388557]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
  • ARFGAP: Putative GTP-ase activating proteins for the small GTPase, ARF
  • Small_GTPase: Small GTPase of the Ras superfamily
  • ill-defined subfamily
  • ANK: ankyrin repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12491
    KEGG - Pathway(s):
    hsa04144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MGC71657; Centaurin, gamma 2 isoform 1; ARF GAP with GTP binding protein like ankyrin repeat and pleckstrin homology domains 1; AGAP1; GGAP1; KIAA1099; GTP binding and GTPase activating protein 1; Centaurin, gamma 2 isoform 2
    Approved Symbol:
    AGAP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16359 Entrez Gene ID: 116987 OMIM ID: 608651 Swissprot Accession: Q9UPQ3;