Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 10)
Summary:
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
  • ARFGAP: Putative GTP-ase activating proteins for the small GTPase, ARF
  • ANK: ankyrin repeats
  • RHOGAP: GTPase-activator protein for Rho-like GTPases
  • RA: Ras association (RalGDS/AF-6) domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12490
    KEGG - Pathway(s):
    hsa04144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    KIAA0782; Cnt-d2; ARF-GAP; RHO-GAP; Ankyrin repeat and pleckstrin homology domains containing protein 1; ARAP1; Arf-GAP Rho-GAP ankyrin repeat and pleckstrin homology domain containing protein 1; Centaurin delta 2 isoform b; Centaurin delta 2 isoform a; Centaurin delta 2 isoform c
    Approved Symbol:
    ARAP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 49
    Human (de-) phosphorylation sites: 49; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09440 Entrez Gene ID: 116985 OMIM ID: 606646 Swissprot Accession: Q96P48; B2RTS2;