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Description for Protein GRIN3A

glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
7 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CC: Coiled Coil
  • PBPE: Eukaryotic homologues of bacterial periplasmic substrate binding proteins.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05213
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NR3A
    Approved Symbol:
    GRIN3A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acamprosate(db);
  • Amantadine(db);
  • Chloroprocaine(db);
  • Dextromethorphan(db);
  • Ethanol(db);
  • Ethopropazine(db);
  • Felbamate(db);
  • Halothane(db);
  • Ketamine(db);
  • L-Glutamic Acid(db);
  • Memantine(db);
  • Methadone(db);
  • Orphenadrine(db);
  • Phencyclidine(db);
  • Procaine(db);
  • Rolicyclidine(db);
  • Tenocyclidine(db);
  • Tramadol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 09443 Entrez Gene ID: 116443 OMIM ID: 606650 Swissprot Accession: Q8TCU5;