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Description for Protein SLC22A12

solute carrier family 22 (organic anion/urate transporter), member 12
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an integral membrane protein primarily found in kidney. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08208
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    OAT4L; Organic anion transporter 4 like; Urate transporter 1; Solute carrier family 22 (urate transporter), member 12; Urate anion exchanger 1; URAT1; RST; Urate anion exchanger 1 isoform a; Urate anion exchanger 1 isoform b
    Approved Symbol:
    SLC22A12
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Renal hypouricemia(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 6
  • Isoform 1 : 9
    • Additional Identifiers:

    HPRD: 06160 Entrez Gene ID: 116085 OMIM ID: 607096 Swissprot Accession: Q96S37;