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Description for Protein RASGRP4

RAS guanyl releasing protein 4
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RasGEF: Guanine nucleotide exchange factor for Ras-like small GTPases
  • EF: EF-hand, calcium binding motif
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • RasGEFN: Guanine nucleotide exchange factor for Ras-like GTPases
  • N-terminal motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12363
    KEGG - Pathway(s):
    hsa04010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RAS guanyl nucleotide-releasing protein 4; Guanyl nucleotide releasing protein 4; RAS guanyl releasing protein 4 variant 2; RAS guanyl releasing protein 4 variant 1
    Approved Symbol:
    RASGRP4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09540 Entrez Gene ID: 115727 OMIM ID: 607320 Swissprot Accession: Q8TDF6; C0LTP3; C0LTP2;