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Description for Protein ATG4A

ATG4 autophagy related 4 homolog A (S. cerevisiae)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.4.22.-
KEGG - Orthology:
K08342
KEGG - Pathway(s):
hsa04140
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Autophagy related cysteine endopeptidase 2; AUTL2; MGC43691; dJ889M15.3; AUT-like 2 cysteine endopeptidase; Autophagy-related cysteine endopeptidase 2 isoform a; Autophagy-related cysteine endopeptidase 2 isoform b
Approved Symbol:
ATG4A
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06455 Entrez Gene ID: 115201 OMIM ID: 300663 Swissprot Accession: Q8WYN0;