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Description for Protein CHUK

conserved helix-loop-helix ubiquitous kinase
67 total interacting proteins; 30 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.10
    KEGG - Orthology:
    K04467
    KEGG - Pathway(s):
    hsa04010; hsa04062; hsa04210; hsa04620; hsa04621; hsa04622; hsa04623; hsa04660; hsa04662; hsa04920; hsa05120; hsa05131; hsa05142; hsa05200; hsa05212; hsa05215; hsa05220; hsa05221; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NFKBIKA; I kappa B kinase alpha; IKKA; I kappa B kinase 1; IKK1
    Approved Symbol:
    CHUK
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 15
    Human phosphorylation targets: 15; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Aminosalicylic Acid(db);
  • Mesalazine(db);
  • Sulfasalazine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02811 Entrez Gene ID: 1147 OMIM ID: 600664 Swissprot Accession: O15111;