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Description for Protein TIRAP

toll-interleukin 1 receptor (TIR) domain containing adaptor protein
18 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TIR: Toll - interleukin 1 - resistance
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05403
    KEGG - Pathway(s):
    hsa04620
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MYD88 adaptor like protein; Mal; Toll interleukin 1 receptor domain containing adapter protein; Adaptor protein Wyatt; Toll-interleukin 1 receptor domain-containing adaptor protein isoform a; FLJ42305; Wyatt; Toll like receptor adaptor protein; Adapter protein wyatt; Toll interleukin 1 receptor domain containing adaptor protein isoform b
    Approved Symbol:
    TIRAP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05878 Entrez Gene ID: 114609 OMIM ID: 606252 Swissprot Accession: P58753; Q56UH9;