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Description for Protein ADCY8

adenylate cyclase 8 (brain)
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • GuCyclase: Adenylyl-/guanylyl cyclase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    4.6.1.1
    KEGG - Orthology:
    K08048
    KEGG - Pathway(s):
    hsa00230; hsa04020; hsa04062; hsa04114; hsa04270; hsa04540; hsa04720; hsa04742; hsa04912; hsa04914; hsa04916; hsa04970; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Adenylyl cyclase, brain type I; Adenylate cyclase 3; ADCY3; HBAC1; ACVIII; AC8; Adenylate cyclase, type VIII; ATP pyrophosphate-lyase; Ca(2+)/calmodulin activated adenylyl cyclase
    Approved Symbol:
    ADCY8
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 9
    • Additional Identifiers:

    HPRD: 00051 Entrez Gene ID: 114 OMIM ID: 103070 Swissprot Accession: Q4F7X0; P40145;