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Description for Protein CHRNA7

cholinergic receptor, nicotinic, alpha 7
5 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04809
    KEGG - Pathway(s):
    hsa04020; hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Acetylcholine receptor neuronal nicotinic alpha 7 subunit; Schizophrenia neurophysiologic defect in
    Approved Symbol:
    CHRNA7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amobarbital(db);
  • Aprobarbital(db);
  • Barbital(db);
  • Barbituric acid derivative(db);
  • Butabarbital(db);
  • Butalbital(db);
  • Butethal(db);
  • Galantamine(db);
  • Heptabarbital(db);
  • Hexobarbital(db);
  • Memantine(db);
  • Metharbital(db);
  • Methylphenobarbital(db);
  • Nicotine(db);
  • Pentobarbital(db);
  • Phenobarbital(db);
  • Primidone(db);
  • Secobarbital(db);
  • Succinylcholine(db);
  • Talbutal(db);
  • Tenocyclidine(db);
  • Thiopental(db);
  • Tramadol(db);
  • Varenicline(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 00339 Entrez Gene ID: 1139 OMIM ID: 118511 Swissprot Accession: P36544;