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Description for Protein CHRNA4

cholinergic receptor, nicotinic, alpha 4
6 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04806
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Acetylcholine receptor, neuronal nicotinic, alpha-4 subunit; Neuronal acetylcholine receptor protein, alpha 4 chain
    Approved Symbol:
    CHRNA4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amobarbital(db);
  • Aprobarbital(db);
  • Barbital(db);
  • Barbituric acid derivative(db);
  • Butabarbital(db);
  • Butalbital(db);
  • Butethal(db);
  • Galantamine(db);
  • Heptabarbital(db);
  • Hexobarbital(db);
  • Metharbital(db);
  • Methylphenobarbital(db);
  • Nicotine(db);
  • Pentobarbital(db);
  • Phenobarbital(db);
  • Primidone(db);
  • Secobarbital(db);
  • Talbutal(db);
  • Thiopental(db);
  • Varenicline(db)

    Associated Genetic Diseases:

  • Epilepsy, nocturnal frontal lobe, type 1(Pd);
  • Nicotine addiction, protection against(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 00333 Entrez Gene ID: 1137 OMIM ID: 118504 Swissprot Accession: P43681;