Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein CHRNA2

cholinergic receptor, nicotinic, alpha 2 (neuronal)
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04804
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Acetycholine receptor neuronal nicotinic alpha 2 subunit
    Approved Symbol:
    CHRNA2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Atracurium(db);
  • Biperiden(db);
  • Carbachol(db);
  • Cisatracurium Besylate(db);
  • Decamethonium(db);
  • Dextromethorphan(db);
  • Doxacurium(db);
  • Doxacurium chloride(db);
  • Galantamine(db);
  • Gallamine Triethiodide(db);
  • Mecamylamine(db);
  • Metocurine(db);
  • Metocurine Iodide(db);
  • Mivacurium(db);
  • Nicotine(db);
  • Pancuronium(db);
  • Pipecuronium(db);
  • Procaine(db);
  • Rocuronium(db);
  • Tubocurarine(db);
  • Vecuronium(db)

    Associated Genetic Diseases:

  • Epilepsy, nocturnal frontal lobe, type 4(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 00332 Entrez Gene ID: 1135 OMIM ID: 118502 Swissprot Accession: Q15822;